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Rochester, New York 14642


The purpose of this study is to determine if omega-3 fatty acids enhance the antiplatelet effects of aspirin.

Study summary:

Although aspirin has been a stalwart treatment in the prevention and treatment of myocardial infarction and stroke, it does not have its expected effects in a significant proportion of the population. This phenomenon has been termed "aspirin resistance". Omega-3 fatty acid supplementation has been associated with a reduced risk of sudden cardiac death and myocardial infarction. The beneficial effects of omega-3s are considered to be partially due to their ability to prevent platelet aggregation. However, the ability of omega-3s to enhance the effects of aspirin in those who suffer from aspirin resistance has not been determined. It is known that aspirin stimulates the production of potent lipid mediators from omega-3 fatty acids and that these mediators have powerful antiinflammatory and tissue-protective effects. Thus, the treatment of individuals at high risk for myocardial infarction and stroke with both aspirin and a pharmaceutical-grade omega-3 fatty acid medication may be a powerful combination in the prevention and treatment of life-threatening cardiovascular disease.


Inclusion Criteria: - Willing to participate by providing informed consent and committing to complete the study. This includes adhering to the study diet. - No chronic disease by history and based on a complete blood count and comprehensive metabolic profile. - Commitment to not taking aspirin, non-steroidal anti-inflammatory medications, and to limit fish intake to ≤2 meals during the 7 days prior to each CRC study period. They will also need to abstain from taking a list of over-the-counter medications that include aspirin. For the duration of the study, they will also be asked to abstain from taking fish and flax seed oil supplements. Exclusion Criteria: - Reports the presence of chronic disease (e.g. cardiovascular, renal, hepatic, neurodegenerative, neoplastic, metabolic {diabetes}, hypertension). - Reports taking a systemic medication chronically. - History of serious adverse reaction or allergy to aspirin or fish oil. - Baseline platelet count <100 000 or >500 000, hematocrit <30%, or white blood cell count >20 000. - Any abnormality from a screening CBC and complete blood count that suggests acute or chronic disease. - Nicotine user. - History of alcohol abuse - Pregnancy by history or urine/serum pregnancy test - History of intestinal malabsorption syndrome including gastric bypass surgery



Primary Contact:

Principal Investigator
Robert C Block, MD, MPH
University of Rochester School of Medicine and Dentistry

Backup Contact:


Location Contact:

Rochester, New York 14642
United States

There is no listed contact information for this specific location.

Site Status: N/A

Data Source: ClinicalTrials.gov

Date Processed: October 09, 2019

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