Expired Study
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New Haven, Connecticut 06519


The purpose of this study is to examine whether guanfacine or carvedilol will attenuate the ability of stress to precipitate smoking lapse behavior in treatment seeking and non-treatment seeking daily smokers. Participants seeking treatment for smoking will participate in a smoking cessation attempt after the laboratory sessions. Also looking at gender differences.


Inclusion Criteria: - ages 18-60 - able to read and write in English - smokers Exclusion Criteria: - any significant current medical conditions that would contraindicate smoking - current Diagnostic and Statistical Manual IV (DSM-IV) abuse or dependence of other substances, other than nicotine (or caffeine) dependence - positive test result at intake appointments on urine drug screens conducted for opiates, cocaine, or benzodiazepines - women who are pregnant or nursing - suicidal, homicidal or evidence of severe mental illness - participants prescribed any psychotropic drug in the 30 days prior to study enrollment - blood donation within the past 6 weeks - participants who have engaged in a quit attempt in the past 3 months - specific exclusions for administration of guanfacine/carvedilol not already specified include: Hypotensive individuals with sitting blood pressure below 90/50 mmHG; EKG evidence at baseline screening of any clinically significant conduction abnormalities, including a Bazett's corrected QT interval (QTc) >450 msec for men and QTc>470 msec for women; known intolerance for guanfacine



Primary Contact:

Principal Investigator
Sherry A McKee, PhD
Yale University

Backup Contact:


Location Contact:

New Haven, Connecticut 06519
United States

There is no listed contact information for this specific location.

Site Status: N/A

Data Source: ClinicalTrials.gov

Date Processed: October 09, 2019

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