Expired Study
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New Haven, Connecticut 06519


Purpose:

The purpose of this study is to examine whether guanfacine or carvedilol will attenuate the ability of stress to precipitate smoking lapse behavior in treatment seeking and non-treatment seeking daily smokers. Participants seeking treatment for smoking will participate in a smoking cessation attempt after the laboratory sessions. Also looking at gender differences.


Criteria:

Inclusion Criteria: - ages 18-60 - able to read and write in English - smokers Exclusion Criteria: - any significant current medical conditions that would contraindicate smoking - current Diagnostic and Statistical Manual IV (DSM-IV) abuse or dependence of other substances, other than nicotine (or caffeine) dependence - positive test result at intake appointments on urine drug screens conducted for opiates, cocaine, or benzodiazepines - women who are pregnant or nursing - suicidal, homicidal or evidence of severe mental illness - participants prescribed any psychotropic drug in the 30 days prior to study enrollment - blood donation within the past 6 weeks - participants who have engaged in a quit attempt in the past 3 months - specific exclusions for administration of guanfacine/carvedilol not already specified include: Hypotensive individuals with sitting blood pressure below 90/50 mmHG; EKG evidence at baseline screening of any clinically significant conduction abnormalities, including a Bazett's corrected QT interval (QTc) >450 msec for men and QTc>470 msec for women; known intolerance for guanfacine


NCT ID:

NCT00773357


Primary Contact:

Principal Investigator
Sherry A McKee, PhD
Yale University


Backup Contact:

N/A


Location Contact:

New Haven, Connecticut 06519
United States



There is no listed contact information for this specific location.

Site Status: N/A


Data Source: ClinicalTrials.gov

Date Processed: October 09, 2019

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