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Richmond, Virginia 23298


The purpose of this study is to determine if prolonged administration of the anti TNF (tumor necrosis factor)-Alpha agent etanercept is associated with enhanced graft survival in patients undergoing islet after kidney transplantation.


Inclusion Criteria: - Patients with type 1 diabetes mellitus, who have a stable functioning renal transplant, are taking the appropriate maintenance immunosuppression and have no severe health problems that preclude them receiving an islet transplant will be considered for inclusion. Exclusion Criteria: - Have a history of or findings suggestive of unstable diabetic complications (e.g. active eye disease) - Active infections (clinically or by laboratory testing) - History of current malignancy or suspicion of malignancy until properly investigated and excluded - Liver or biliary abnormalities - Unstable cardiovascular disease - Findings to suggest immunological sensitization or those women who have the potential to get pregnant and are not using a sufficient method of contraception



Primary Contact:

Principal Investigator
Adrian H Cotterell, M.D.
Virginia Commonwealth University Health System

Backup Contact:


Location Contact:

Richmond, Virginia 23298
United States

There is no listed contact information for this specific location.

Site Status: N/A

Data Source: ClinicalTrials.gov

Date Processed: October 09, 2019

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