Expired Study
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Nashville, Tennessee 37212


Purpose:

Aim1a: Statin naive patient's scheduled for cardiac surgery will be randomized to 80mg atorvastatin or placebo on the day prior to surgery and then 40mg daily thereafter until hospital discharge to test the hypothesis that short-term atorvastatin use decreases: 1. acute kidney injury following cardiac surgery. 2. postoperative delirium following cardiac surgery. Aim1b: Patients using statins preoperatively will be randomized to atorvastatin 80mg or placebo on day of surgery and 40mg or placebo on postop day 1 with resumption of preoperative statin therapy on postop day 2 to test the hypothesis that short-term atorvastatin use decreases: 1. acute kidney injury following cardiac surgery. 2. postoperative delirium following cardiac surgery. Endpoints include glomerular filtration, urine and plasma markers of renal dysfunction, markers of oxidative stress, mitochondrial function, systemic inflammatory markers, delirium, dialysis, stroke, myocardial infarction, time to extubation, ICU length of stay, and death.


Criteria:

Inclusion Criteria: - open heart surgery Exclusion Criteria: - acute coronary syndrome with troponin leak or unrelenting angina - liver dysfunction (transaminases 2x normal) - history of myopathy or liver dysfunction on prior statin therapy - use of potent CYP3A4 inhibitors such as antifungal azoles, macrolide antibiotics, HIV protease inhibitors, and nefazodone. - pregnancy or breast feeding - cyclosporine use - dialysis - history of kidney transplant - fibrate users who cannot stop fibrate use.


NCT ID:

NCT00791648


Primary Contact:

Principal Investigator
Frederic T. Billings, IV, MD
Vanderbilt University


Backup Contact:

N/A


Location Contact:

Nashville, Tennessee 37212
United States



There is no listed contact information for this specific location.

Site Status: N/A


Data Source: ClinicalTrials.gov

Date Processed: October 09, 2019

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