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Scranton, Pennsylvania 18509


The purpose of this study is to examine if the ingestion of a standard dose of sildenafil enhances the athletic performance of competitive athletes when exercising in a high pollutant environment verses a low air pollutant environment.

Study summary:

This study will evaluate effects of sildenafil on exercise performance while breathing high levels of emission exhaust ultrafine and fine particulate matter. Exercise performance will be measured by work accumulation (total kJ) during a 6-min maximal effort cycle ergometer ride (CER) done immediately after 30 min cycling at 75% of 6 min mean watts determined from familiarization trial. Peak oxygen consumption, cardiac output, pulmonary artery pressure, diffusion capacity(DLco), and SaO2 will be determined for each trial. Blood and urine will be analyzed for sildenafil using LC/MS.


Inclusion Criteria: - non-asthmatic - asthmatic - active participants in endurance sports. Exclusion Criteria: - history of high blood pressure - history of heart disease - pulmonary arterial hypertension - pulmonary emboli - diagnosis of moderate to severe asthma (FEV1 <75% predicted) - pregnant or lactating



Primary Contact:

Principal Investigator
Kenneth W Rundell, Ph.D.
Marywood University

Backup Contact:


Location Contact:

Scranton, Pennsylvania 18509
United States

There is no listed contact information for this specific location.

Site Status: N/A

Data Source: ClinicalTrials.gov

Date Processed: October 09, 2019

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