Bethesda, Maryland 20892

  • Breast Cancer

Purpose:

RATIONALE: Studying samples of tumor tissue from patients with cancer in the laboratory may help doctors predict how well patients will respond to treatment. PURPOSE: This laboratory study is looking at tumor tissue samples from women with node-positive breast cancer.


Study summary:

OBJECTIVES: - Determine whether levels of phosphorylated Akt (protein kinase B) are associated with disease-free and/or overall survival in women with node-positive breast cancer treated with doxorubicin hydrochloride and cyclophosphamide or doxorubicin hydrochloride, cyclophosphamide, and paclitaxel on protocol NSABP-B-28. - Compare whether patients with pAkt-negative vs pAkt-positive tumors have a superior disease-free survival with the addition of paclitaxel than those treated with doxorubicin hydrochloride and cyclophosphamide alone. OUTLINE: Tissue microarray sections are analyzed for levels of pAkt by immunohistochemistry. PROJECTED ACCRUAL: A total of 3,060 patients will be accrued for this study within 3 years.


Criteria:

DISEASE CHARACTERISTICS: - Diagnosis of breast cancer - Operable disease - Histologically confirmed positive axillary lymph nodes - Prior enrollment on NSABP-B-28 required - Preserved tumor tissue microarray blocks from the NSABP-B-28 study available - Hormone receptor status: - Not specified PATIENT CHARACTERISTICS: Age - 18 to 78 Sex - Female Menopausal status - Not specified Performance status - Not specified Life expectancy - Not specified Hematopoietic - Not specified Hepatic - Not specified Renal - Not specified PRIOR CONCURRENT THERAPY: Biologic therapy - Not specified Chemotherapy - Not specified Endocrine therapy - Not specified Radiotherapy - Not specified Surgery - Not specified


NCT ID:

NCT00896870


Primary Contact:

Study Chair
Xiaowei Yang, MD, PhD
National Cancer Institute (NCI)


Backup Contact:

N/A


Location Contact:

Bethesda, Maryland 20892
United States

Clinical Trials Office - Warren Grant Magnusen Clinical Center
Phone: 888-NCI-1937

Site Status: Recruiting


Data Source: ClinicalTrials.gov

Date Processed: November 27, 2022

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