New York, New York 10032

  • Lymphoma

Purpose:

RATIONALE: Collecting and storing stem cells to study in the laboratory may help doctors learn more about collecting stem cells from patients who have undergone treatment for Waldenstrom's macroglobulinemia. PURPOSE: This laboratory study is collecting stem cells from patients with Waldenstrom's macroglobulinemia.


Study summary:

OBJECTIVES: - Harvest and store adequate CD34+ stem cells from patients with Waldenstrom's macroglobulinemia (WM) for potential future use in transplantation strategies. - Evaluate the ability to harvest stem cells after therapy for WM (e.g., fludarabine-based chemotherapy) by evaluating the number of days to adequate harvest. - Collect aliquots of stem cells for future research analysis as part of a WM database project. OUTLINE: Patients undergo collection of autologous stem cells beginning on day 4 or 5 and continuing until an adequate number of stem cells are collected. Cells are then cryopreserved. PROJECTED ACCRUAL: A total of 40 patients will be accrued for this study.


Criteria:

DISEASE CHARACTERISTICS: - Diagnosis of Waldenstrom's macroglobulinemia (WM) - Less than 30% lymphoplasmacytoid cells in bone marrow by histopathology - Received prior chemotherapy for WM PATIENT CHARACTERISTICS: - ECOG performance status 0-1 - WBC > 2,000/mm³ - Platelet count > 50,000/mm³ - LVEF ≥ 50% - No organ dysfunction that would preclude future transplantation PRIOR CONCURRENT THERAPY: - See Disease Characteristics


NCT ID:

NCT00899119


Primary Contact:

Study Chair
Gwen L. Nichols, MD
Herbert Irving Comprehensive Cancer Center


Backup Contact:

N/A


Location Contact:

New York, New York 10032
United States

Clinical Trials Office - Herbert Irving Comprehensive Cancer C
Phone: 212-305-8615

Site Status: Recruiting


Data Source: ClinicalTrials.gov

Date Processed: December 07, 2022

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