Expired Study
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Baltimore, Maryland 21224


Purpose:

The prevalence of obesity and asthma has significantly increased over the past two decades. The purpose of this study is to try and understand the mechanism by which obesity leads to airway hyperresponsiveness (AHR), one of the defining features of asthma. This research is being done to determine how weight or body size affects airway size and airway smooth muscle (ASM) tone and function. The goal of the study will be to look at if and how, weight might affect lung functioning. The investigators hypothesize that low lung volumes in obesity lead to AHR by reducing airway caliber causing increased ASM tone with impairment in deep inspiration (DI) response similar to what is seen in asthma.


Criteria:

Inclusion Criteria: - Age 18 years or older - BMI over 35 kg/m2 (Bariatric) or BMI between 25 and 28 kg/m2 (Control) - Physician diagnosis of asthma and on active asthma medication (if asthmatic) Exclusion Criteria: - Weight greater than 450 lbs - Unstable cardiovascular disease - Uncontrolled hypertension - Renal failure on dialysis - Cirrhosis - Pregnant or lactating - Bleeding disorders or Coumadin use - Recent hospitalization for asthma in the past 3 months - Active smoking or more than 10 pack year smoking history


NCT ID:

NCT01127399


Primary Contact:

Principal Investigator
Emmanuelle Clerisme-Beaty, MD, MHS
The Johns Hopkins University


Backup Contact:

N/A


Location Contact:

Baltimore, Maryland 21224
United States



There is no listed contact information for this specific location.

Site Status: N/A


Data Source: ClinicalTrials.gov

Date Processed: August 31, 2019

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