Expired Study
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Austin, Texas 78744


Purpose:

This Phase I, open-label, sequential, single-center study evaluates the pharmacokinetics of digoxin when coadministered with albiglutide in healthy adult subjects.


Study summary:

This Phase I, open-label, sequential, single-center study evaluates the pharmacokinetics of digoxin when coadministered with albiglutide in healthy adult subjects. Subjects will receive a single dose of digoxin on Day 1 followed by 5 weekly subcutaneously injected doses of albiglutide and a second single dose of digoxin on Day 38. To determine the plasma pharmacokinetic parameters of digoxin after drug administration alone and after multiple doses of albiglutide, blood samples will be collected after each dose of digoxin.


Criteria:

Inclusion Criteria: - healthy volunteers - female subjects must be of nonchildbearing potential - no clinically significant diseases or clinically significant abnormal laboratory values - body mass index (BMI) is >/=18 kg and ≤30 kg/m2 - a nonsmoker Exclusion Criteria: - positive test results for hepatitis B, hepatitis C or human immunodeficiency virus - female subject is pregnant or breast-feeding - history of any anaphylactic reaction to any drug - history of significant cardiovascular or pulmonary dysfunction - current or chronic history of liver disease - history of alcohol or substance abuse - history of thyroid disease or dysfunction - history of gastrointestinal surgery or disease - history of pancreatitis - history of cholecystitis or other gallbladder disease - previously received any GLP-1 mimetic compound (e.g., exenatide)


NCT ID:

NCT01147718


Primary Contact:

Study Director
GSK Clinical Trials
GlaxoSmithKline


Backup Contact:

N/A


Location Contact:

Austin, Texas 78744
United States



There is no listed contact information for this specific location.

Site Status: N/A


Data Source: ClinicalTrials.gov

Date Processed: August 31, 2019

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