Expired Study
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Durham, North Carolina 27710


Purpose:

The purpose of this study is to examine the effects of using dexmedetomidine (Precedex) in addition to the current standard-of-care for sedation.


Study summary:

Primarily, this study seeks to explore whether there is a difference in mean arterial pressure (MAP) variability, incidence of intracranial hypertension, intracranial pressure (ICP) variability, cerebral perfusion pressure (CPP) and Cerebrovascular pressure reactivity index (PRx) in two groups of subjects. Patients must be submitted to the ICU and be endotracheally intubated and receiving mechanical ventilation with continuous IV sedation for less than 24 hours after recruitment into the study.


Criteria:

Inclusion Criteria: - Admitted to Duke University NCCU - Adult (18 years of age or older) - Expected Mechanical Ventilation for >48 hours with sedation - Intraventricular catheter in situ Exclusion Criteria: - Hypersensitivity to study drugs - Prisoners - Moribund state or death expected within 24 hours - Surgery planned within 24 hours of subject enrollment - Receiving study drug, Precedex, prior to entering study


NCT ID:

NCT01169467


Primary Contact:

Principal Investigator
Keith Dombrowski, MD
Duke University


Backup Contact:

N/A


Location Contact:

Durham, North Carolina 27710
United States



There is no listed contact information for this specific location.

Site Status: N/A


Data Source: ClinicalTrials.gov

Date Processed: August 31, 2019

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