Portland, Oregon 97239


Purpose:

The standard of care treatment of sudden hearing loss uses a type of steroid called glucocorticoid. Examples of glucocorticoids are prednisone, methylprednisolone and dexamethasone. Not everybody recovers hearing with glucocorticoid treatment. Fludrocortisone is a different type of steroid called mineralocorticoid. Unlike glucocorticoids, which work by reducing inflammation, mineralocorticoids work by changing salt and fluid balance. In animal studies, fludrocortisone is at least as effective as glucocorticoid in preserving hearing. Fludrocortisone is not approved for the treatment of sudden hearing loss. The purpose of this study is to test whether fludrocortisone can treat sudden hearing loss.


Criteria:

Inclusion Criteria: - Age 18 or older - Idiopathic sudden sensorineural hearing loss within 3 months - Failure to recover hearing with glucocorticoid treatment or inability to tolerate glucocorticoid Exclusion Criteria: - Other diagnosis for the sudden hearing loss - Concurrent systemic use of another steroid - Hypersensitivity to fludrocortisone - Systemic fungal infection - Hypertension requiring two or more medications - Pitting edema - Cardiomegaly - Congestive heart failure - Electrolyte abnormality - Concurrent use of barbiturates, phenytoin, fosphenytoin, rifampin, or rifapentine


NCT ID:

NCT01186185


Primary Contact:

Principal Investigator
Anh Nguyen-Huynh, MD PhD
Oregon Health and Science University

Anh Nguyen-Huynh, MD PhD
Phone: 503-494-8135
Email: nguyanh@ohsu.edu


Backup Contact:

N/A


Location Contact:

Portland, Oregon 97239
United States

Anh Nguyen-Huynh
Phone: 503-260-9192
Email: nguyanh@ohsu.edu

Site Status: Recruiting


Data Source: ClinicalTrials.gov

Date Processed: August 31, 2019

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