Rochester, Minnesota 55905


Multiple studies have examined the effect of endogenous GLP-1 secretions by using a competitive antagonist of GLP-1 - Exendin-9,39 - infused at rates of 300pmol/kg/min. However, the presence of an effect does not necessarily imply that this effect is due to the blockade of the endogenous GLP-1 actions at the receptor. It is possible that the supraphysiologic concentrations of Exendin may have effects of its own. To examine the effect of Exendin on glucose metabolism the investigators propose a dose-response study to determine whether the compound has effects in a dose-dependent fashion.


Healthy Not on any medication other than thyroid hormone replacement or OCP No history of diabetes No prior upper GI surgery



Primary Contact:

Principal Investigator
Adrian Vella, MD
Mayo Clinic

Backup Contact:


Location Contact:

Rochester, Minnesota 55905
United States

Adrian Vella, MD

Site Status: Recruiting

Data Source:

Date Processed: August 31, 2019

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