Expired Study
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San Francisco, California 94143


In this study the investigators will test a nutritional supplement called betaine hydrochloride to see if it can temporarily increase the stomach acid in healthy volunteers who have decreased stomach acid because they take a medicine called rabeprazole.


Inclusion Criteria: - Healthy adult with no active medical problems or significant chronic diseases as determined by the study doctor based on history, physical exam; - BMI between 18.5 - 35 kg/m2; - Taking no medications 2 weeks before and during the study enrollment, including drugs of abuse, prescription or OTC medications (except acetaminophen); - Subjects must be able to maintain adequate birth control during the study independent of hormonal contraceptive use; - Be able to provide written informed consent and comply with requirements of the study; - Avoid eating grapefruit and drinking grapefruit juice from 7 days before the first study day until completion of the entire study; - Abstinence from alcoholic beverages, caffeinated beverages and orange juice from 6pm the night before a study day until completion of that study day; - Fast from food and beverages at least 8 hours prior to the study day; - Be able to read, speak and understand English Exclusion Criteria: - Subjects with a history of gastrointestinal disease including gastroesophageal reflux disease, gastritis, peptic ulcer disease or dyspepsia. - Subjects with a fasting gastric pH of > 4 (i.e. hypochlorhydria) - Subjects with history of dysphagia, achalasia, or difficulty swallowing capsules, tablets or pills. - Subjects on prescription or chronic over-the counter medications (including hormonal contraceptives); - Subjects with known allergy to study interventions; - Subjects who smoke tobacco; - Subjects with ongoing alcohol or illegal drug use; - Subjects who are pregnant, lactating or attempting to conceive; - Subjects unable to maintain adequate birth control during the study; - Subjects unable to follow protocol instructions or protocol criteria.



Primary Contact:

Principal Investigator
Leslie Benet, PhD
University of California, San Francisco

Backup Contact:


Location Contact:

San Francisco, California 94143
United States

There is no listed contact information for this specific location.

Site Status: N/A

Data Source: ClinicalTrials.gov

Date Processed: August 31, 2019

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