Expired Study
This study is not currently recruiting Study Participants on ClinicalConnection.com. If you would like to find active studies please search for clinical trials.

San Francisco, California 94143


Purpose:

In this study the investigators will test a nutritional supplement called betaine hydrochloride to see if it can temporarily increase the stomach acid in healthy volunteers who have decreased stomach acid because they take a medicine called rabeprazole.


Criteria:

Inclusion Criteria: - Healthy adult with no active medical problems or significant chronic diseases as determined by the study doctor based on history, physical exam; - BMI between 18.5 - 35 kg/m2; - Taking no medications 2 weeks before and during the study enrollment, including drugs of abuse, prescription or OTC medications (except acetaminophen); - Subjects must be able to maintain adequate birth control during the study independent of hormonal contraceptive use; - Be able to provide written informed consent and comply with requirements of the study; - Avoid eating grapefruit and drinking grapefruit juice from 7 days before the first study day until completion of the entire study; - Abstinence from alcoholic beverages, caffeinated beverages and orange juice from 6pm the night before a study day until completion of that study day; - Fast from food and beverages at least 8 hours prior to the study day; - Be able to read, speak and understand English Exclusion Criteria: - Subjects with a history of gastrointestinal disease including gastroesophageal reflux disease, gastritis, peptic ulcer disease or dyspepsia. - Subjects with a fasting gastric pH of > 4 (i.e. hypochlorhydria) - Subjects with history of dysphagia, achalasia, or difficulty swallowing capsules, tablets or pills. - Subjects on prescription or chronic over-the counter medications (including hormonal contraceptives); - Subjects with known allergy to study interventions; - Subjects who smoke tobacco; - Subjects with ongoing alcohol or illegal drug use; - Subjects who are pregnant, lactating or attempting to conceive; - Subjects unable to maintain adequate birth control during the study; - Subjects unable to follow protocol instructions or protocol criteria.


NCT ID:

NCT01237353


Primary Contact:

Principal Investigator
Leslie Benet, PhD
University of California, San Francisco


Backup Contact:

N/A


Location Contact:

San Francisco, California 94143
United States



There is no listed contact information for this specific location.

Site Status: N/A


Data Source: ClinicalTrials.gov

Date Processed: August 31, 2019

Modifications to this listing: Only selected fields are shown, please use the link below to view all information about this clinical trial.


Click to view Full Listing

This study is not currently recruiting Study Participants on ClinicalConnection.com. The form below is not enabled.