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Los Angeles, California 90033


The purpose of this study is to determine the effect of anti-VEGF drug (Avastin) adminstration in eyes prior to surgical treatment for Traction retinal detachment (TRD) in patients with Proliferative Diabetic Retinopathy (PDR).

Study summary:

Traction retinal detachment (TRD) due to proliferative diabetic retinopathy is a blinding disease caused by contraction of fibrovascular proliferation, treatment of which is limited to surgery. Fibrosis and neovascularization are both associated with high levels of connective tissue growth factor (CTGF) and vascular endothelial growth factor (VEGF) in the eye. Small, nonrandomized studies have suggested that pre-operative adjunctive anti-VEGF administration may reduce intra- and post-operative complications and provide visual benefit in patients with this condition.


Inclusion Criteria: - Active fibrovascular proliferation due to PDR with TRD given pre-operative clearance for pars plana vitrectomy (PPV) and TRD repair. Exclusion Criteria: - Dense vitreous hemorrhage - Inability to follow-up for surgery within 3-7 days after intravitreal injection - History of stroke, thromboembolic event, or heart attack within the last 6 months - Less than 18 years of age - Pregnancy



Primary Contact:

Principal Investigator
Dean Eliott, MD
University of Southern California

Backup Contact:


Location Contact:

Los Angeles, California 90033
United States

There is no listed contact information for this specific location.

Site Status: N/A

Data Source: ClinicalTrials.gov

Date Processed: August 31, 2019

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