Expired Study
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Chicago, Illinois 60611


The purpose of this study is to determine whether a neuropeptide, substance P, when injected along with an allergen, such as ragweed, can reduce allergic reactivity.

Study summary:

Allergic Rhinitis (Hay fever) affects many children and adults and is a risk factor for development of asthma. This study utilizes the neurotransmitter, substance P, a small molecule which is present in nerve endings, the brain, skin, lungs and the gastrointestinal tract. Subjects will receive substance P and a low dosage of an allergen, such as ragweed in an attempt to reduce allergic reactivity.


Inclusion Criteria: - positive immediate type skin test to ragweed or grass pollen or a third (standardized) allergen if both ragweed and grass pollen allergen are not positive - volunteers should be available for allergen injections and then cutaneous titrations for approximately 1 year from the start of the enrollment period Exclusion Criteria: - volunteer is pregnant or lactating - abnormal electrocardiogram for subjects over 50 years of age - use of beta adrenergic antagonists or tricyclic antidepressants



Primary Contact:

Principal Investigator
Paul A Greenberger, M.D.
Northwestern University Feinberg School of Medicine

Backup Contact:


Location Contact:

Chicago, Illinois 60611
United States

There is no listed contact information for this specific location.

Site Status: N/A

Data Source: ClinicalTrials.gov

Date Processed: August 31, 2019

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