Expired Study
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Pittsburgh, Pennsylvania 15224


Purpose:

Blacks are at increased risk for obesity, type 2 diabetes mellitus and cardiovascular disease. A common pathogenetic link among these entities is insulin resistance/hyperinsulinemia. The specific aims of this project are: 1) to compare skeletal muscle lipid content (SMLC) in black vs white children by computed tomography (CT) scan of the mid-thigh, and assess the relationship to in vivo insulin sensitivity; 2) to test the hypothesis that free fatty acid (FFA) - induced insulin resistance is associated with larger increases in intramyocellular lipid (IMCL) in black vs white adolescents; 3) to examine if β-cell insulin secretion in prepubertal black children is more sensitive to the stimulatory effect of FFA than in whites; and 4) to test if the β-cell in black obese adolescents is more susceptible to the lipotoxic effect of FFA compared with whites. The methods to be used are: the well- established CT method as well as Magnetic Resonance Spectroscopy (1H-MRS) to assess SMLC and IMCL; intralipid infusion to elevate circulating FFA levels; the hyperinsulinemic-euglycemic clamp with stable isotopes and indirect calorimetry to measure insulin sensitivity and substrate turnover; the hyperglycemic clamp to assess insulin secretion; DEXA and whole body MRI for body composition assessments.


Criteria:

Inclusion Criteria: Protocols 1 & 4: - Age 11-17 years - Male or Female - Healthy - Obese, BMI ≥ 95 percentile - Pubertal/Tanner Stage II-V - African American or White American, based on self identity with no admixture for 3 generations Protocol 2: - Age 11-17 years - Male or Female - Healthy - Normal Weight, BMI 10- 95 percentile - Pubertal/Tanner Stage II-V - African American or White American, based on self-identity with no admixture for 3 generations Protocol 3: - Age 8-12 years - Male or Female - Healthy - Normal Weight, BMI 10-95 percentile - Prepubertal/Tanner Stage I - African American or White American, based on self-identity with no admixture for 3 generations Exclusion Criteria: - Medications which interfere with metabolism - Hemocue < 12 gm/dl in pubertal subjects and <11gm/dl in prepubertal subjects - Positive serum pregnancy test - Recent significant weight change or dieting - Presence of disease (i.e.diabetes, hypothyroidism, genetic dyslipidemia, etc)


NCT ID:

NCT01312051


Primary Contact:

N/A


Backup Contact:

N/A


Location Contact:

Pittsburgh, Pennsylvania 15224
United States



There is no listed contact information for this specific location.

Site Status: N/A


Data Source: ClinicalTrials.gov

Date Processed: August 31, 2019

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