San Francisco, California 94110


This study involved the medical record review of resuscitation records for all severely-injured trauma patients requiring emergent surgical intervention and significant acidosis from 2005 through 2009.

Study summary:

The study objective is to assess the efficacy of fluid resuscitation and treatment of acidosis in patients who were managed with use of amine buffer THAM (tris-hydroxymethlaminomethane) versus those who were resuscitated with crystalloids or colloids and may have have received sodium bicarbonate for the treatment of acidosis.


Inclusion Criteria: - Presence of severe traumatic injury requiring emergent surgery - Peri-operative development of severe acidosis (defined arterial ph less than or equal to 7.20 or base deficit greater than or equal to 10 mEq/dL) - Acidosis was treated with either THAM or "usual care" (defined as crystalloid either or without sodium bicarbonate) Exclusion Criteria: - None



Primary Contact:

Principal Investigator
Julin Tang, MD
University of California, San Francisco

Julin F Tang, MD
Phone: 415-206-5274

Backup Contact:

Gus Pangan, MBA
Phone: (415) 206-5274

Location Contact:

San Francisco, California 94110
United States

Julin Tang, MD
Phone: 415-206-5274

Site Status: Recruiting

Data Source:

Date Processed: August 31, 2019

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