Expired Study
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Ocala, Florida 34471


Purpose:

This randomized, double-blind, placebo-controlled study will evaluate the efficacy and safety of RO4905417 in patients with non ST-elevation myocardial infarction (Non-STEMI) undergoing percutaneous coronary intervention (PCI). Patients will be randomized to receive an intravenous infusion of either 5 mg/kg RO4905417 or 20 mg/kg RO4905417 or placebo before PCI. Follow-up will be for 4 months.


Criteria:

Inclusion Criteria: - Adult patients, >18 to <75 years of age - Non ST-elevation myocardial infarction - Woman of childbearing potential will be allowed only if using two acceptable methods of contraception - Body mass index (BMI) </= 40 kg/m2 Exclusion Criteria: - Acute ST-elevation myocardial infarction (STEMI) - Culprit coronary lesion with a total thrombotic occlusion or a lesion requiring the use of distal embolization protection or thrombectomy devices - Percutaneous coronary intervention (PCI) within the past 72 hours - Thrombolytic therapy within the past 7 days - Major surgery within the past 3 months - History of cerebral vascular disease or stroke in the past 3 months - Bleeding disorders - Inadequately controlled severe hypertension - Prior coronary artery bypass graft (CABG) surgery - Decompensated heart failure (oedema and/or rale) - Acute infection at screening or active chronic infection within 3 months prior to PCI - Patients known to be HIV positive, patients receiving antiretroviral drugs, or immuno-suppressed patients - Uncontrolled diabetes mellitus (HbA1C >10%) at baseline


NCT ID:

NCT01327183


Primary Contact:

Study Director
Clinical Trials
Hoffmann-La Roche


Backup Contact:

N/A


Location Contact:

Ocala, Florida 34471
United States



There is no listed contact information for this specific location.

Site Status: N/A


Data Source: ClinicalTrials.gov

Date Processed: October 09, 2019

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