Expired Study
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New York, New York 10021


Purpose:

Currently, the regional anesthetic standard of care for total knee replacement surgery is combined spinal/epidural, with or without a femoral nerve block, or FNB. Lasting approximately 18 hours, the FNB works by numbing the femoral nerve (and its branches), which is the major nerve controlling the knee joint. The femoral nerve also provides movement and sensation. While this regional anesthetic technique offers significant postoperative pain relief, it is possible that it may cause muscle weakness and increase patients' recovery time. Hence there is a need for an alternative technique, one that may help minimize postoperative pain as effectively as the FNB, while not causing weakness of the quadriceps muscle. The saphenous nerve, a branch of the femoral nerve, provides sensation to the knee. Thus it is hypothesized that by "blocking" or anesthetizing the saphenous nerve with local anesthetic closer to where it branches off, the area around and below the knee will feel numb. Yet unlike with the FNB, the quadriceps muscle itself will still be able to function. Patients will be randomized to receive FNB or saphenous nerve block. Quadriceps strength will be tested using a dynamometer before surgery (baseline), 6-8 hours following anesthesia administration, and on postoperative days 1 and 2. It is hypothesized that patients who receive FNB will experience a 50% decrease in quadriceps strength compared to baseline.


Criteria:

Inclusion Criteria: - All patients ages 18-90 undergoing primary unilateral total knee arthroplasty - Planned use of neuraxial anesthesia - Ability to follow study protocol - American Society of Anesthesiology (ASA) Class 1-3 Exclusion Criteria: - Contraindication to a spinal or epidural anesthetic - Chronic opioid use (defined as daily or almost daily use of opioids for >3 months) - Hypersensitivity and/or allergy to local anesthetics - Intraoperative use of any volatile anesthetic - Patients with a pre-existing neuropathy on the operative limb - Contraindication to a femoral nerve block or saphenous nerve block - Allergy to any of the study medications - Non-English speaking patients


NCT ID:

NCT01333943


Primary Contact:

Principal Investigator
David H. Kim, MD
Hospital for Special Surgery, New York


Backup Contact:

N/A


Location Contact:

New York, New York 10021
United States



There is no listed contact information for this specific location.

Site Status: N/A


Data Source: ClinicalTrials.gov

Date Processed: August 31, 2019

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