Expired Study
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Cincinnati, Ohio 45267


Purpose:

The purpose of this research study is to explore what role immune cells within the gut (the sigmoid colon) have locally and on the immune system of patients infected with HCV, HIV or HCV/ HIV co-infection.


Study summary:

Objective 1: Characterization of the Gut Associated Lymphocytes (GALT) in HIV, HCV and coinfected patients regarding the role of Th17 and cytokine profiles. Hypothesis 1a: HIV and HCV/HIV coinfection is associated with changes in Th17 numbers and functions in GALT. Hypothesis 1b: HIV and HCV/HIV coinfection is associated with changes in cytokine profiles in intestinal mucosa. Objective 2: Identify the relationship between changes in Gut Associated Lymphocytes (GALT) in HIV, HCV and coinfected patients and markers of microbial translocation. Hypothesis 2a: Changes in GALT are associated with increase in microbial translocation in HIV, HCV and coinfected patients.


Criteria:

Inclusion Criteria: - are at least age 18, but not older than 70 years old - have HIV, HCV or both - do not have HIV, HCV or both, and are having a screening colonoscopy or flexible sigmoidoscopy for abdominal pain or colon cancer screening (control subject) Exclusion Criteria: - have a history of inflammatory bowel diseases (IBD) or suspected IBD - have a history of autoimmune diseases including rheumatoid arthritis - are taking systemic immunomodulators - are pregnant


NCT ID:

NCT01335230


Primary Contact:

Principal Investigator
M. Tarek Shata, MD, PhD
University of Cincinnati


Backup Contact:

N/A


Location Contact:

Cincinnati, Ohio 45267
United States



There is no listed contact information for this specific location.

Site Status: N/A


Data Source: ClinicalTrials.gov

Date Processed: August 31, 2019

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