Bethesda, Maryland 20892

  • Unspecified Adult Solid Tumor, Protocol Specific


RATIONALE: Collecting and studying samples of blood from workers exposed to high doses of radiation may help the study of cancer in the future. PURPOSE: This clinical trial is studying gene changes and risk factors in nuclear workers in Mayak, Russia.

Study summary:

OBJECTIVES: - Assess genetic polymorphism contribution in stable chromosome aberration frequency in nuclear workers in Mayak, Russia exposed to high-doses of radiation. OUTLINE: This is a multicenter study. Blood samples are collected annually during routine medical exams to assess intermediate biomarkers of radiation exposure. Samples are analyzed by mBAND biodosimetry and mFISH to measure intrachromosomal aberrations. Germline genetic variation in DNA repair and other genes is also assessed as a risk factor for chromosomal aberration frequency. Participants complete a short questionnaire assessing their jobs, as well as history of family health, smoking and alcohol consumption, and benign tumors, if any. Additional information is obtained from participants' medical records.


DISEASE CHARACTERISTICS: - Meets one of the following criteria: - Nuclear worker in Mayak, Russia who has had notable and atypical radiation exposure - Employed from 1948 to 1972 in 1 of 3 Ozyorsk plants directly related to nuclear weapon production - Remains a local resident - Estimates of external gamma dose and internal plutonium exposure available - Workers who did not have any plutonium exposure are still eligible due to their external radiation exposure - Current or former worker in auxiliary plant (water treatment plant or mechanical repair plant) at the Mayak facility - Cancer-free - No Tartars or Bashkirs PATIENT CHARACTERISTICS: - See Disease Characteristics PRIOR CONCURRENT THERAPY: - No radiation therapy or blood transfusion within the past year



Primary Contact:

Study Chair
Elaine Ron, MD
National Cancer Institute (NCI)

Backup Contact:


Location Contact:

Bethesda, Maryland 20892
United States

Clinical Trials Office - Warren Grant Magnusen Clinical Center
Phone: 888-NCI-1937

Site Status: Recruiting

Data Source:

Date Processed: February 03, 2023

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