Expired Study
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Baltimore, Maryland 21224


Purpose:

This research is being done to see if a drug called escitalopram (Lexapro) is helpful to people who are suffering from depression after traumatic brain injury (TBI).


Study summary:

Despite it's high prevalence, little is known about the pharmacological treatment of depression following Traumatic Brain Injury (TBI). This is because of a lack of randomized controlled studies in the treatment of post-TBI depression. This study is designed to examine the safety and effectiveness of escitalopram in the treatment of post-TBI depression. It will also investigate metabolic changes and neural pathways associated with post-TBI depression and metabolic alterations after treatment through neuroimaging.


Criteria:

Inclusion Criteria: - Closed head injury - Fulfill DSM IV criteria "Major Depressive Disorder" - 18 years of age or older - Able to provide informed consent - Stable medical history Exclusion Criteria: - History of Stroke, Encephalitis, Seizures, or any other pre-TBI neurological diseases - History of mental retardation - Alcohol or Substance dependence in the last 1 year - Inability to undergo MRI scan - Pregnancy - Current use of any psychotropic medications including any antidepressants, antipsychotics, anxiolytics, or sedative hypnotics - Poor response to escitalopram in the past - Acutely suicidal or requiring inpatient psychiatric hospitalization, as determined by the study psychiatrist - Good medication response to another antidepressant in the past


NCT ID:

NCT01368432


Primary Contact:

Principal Investigator
Vani Rao, M.D
Johns Hopkins University


Backup Contact:

N/A


Location Contact:

Baltimore, Maryland 21224
United States



There is no listed contact information for this specific location.

Site Status: N/A


Data Source: ClinicalTrials.gov

Date Processed: August 31, 2019

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