Flushing, New York 11355

  • Delirium

Purpose:

A study will be conducted to determine if there is any cognitive benefit in elderly patients having open versus minimally invasive colon cancer surgery.


Study summary:

Cognitive changes in the elderly are common after surgery. It is not known if minimally invasive or laparoscopic surgery can prevent these changes. A study will be conducted on patients scheduled to have abdominal surgery. The patients will have cognitive evaluations before and after surgery. A small amount of blood, about 2 tablespoons, will be collected no more than 5 times in 6 months. The results will be analyzed to determine if there are changes between those having open surgery versus patients having laparoscopic or minimally invasive surgery, and if these changes coincide with cognitive changes.


Criteria:

Inclusion Criteria: - Patients over age 65.0 years and in need of elective colon resection for adenocarcinoma Exclusion Criteria: - Inability to complete preoperative cognitive screening - Inability to complete study in English since CANTAB is timed and not validated with interpreters - Emergency surgery - Depression or psychiatric comorbidity - Pre-existing dementia - Previous cerebrovascular accident or "stroke" - Previous myocardial infarction - Cardiac ejection fraction below 55% - Propranolol, metoprolol or other betablocker use - Digoxin, procainamide, or amiodarone use - Calcium channel blocker use - History of vascular surgery or arterial vascular disease - History of alcohol dependence - Lovastatin or other HMG-CoA reductase inhibitor use - Ace inhibitor use - Neuroendocrine or catecholamine associated tumors - Hypertension - Diabetes - Benzodiazepine use - Dimenhydrinate or other medications to treat motion sickness - Metaclopramide use


NCT ID:

NCT01623297


Primary Contact:

Principal Investigator
Mitchell I Chorost, MD
New York Hospital Queens

Mitchell Chorost, MD
Phone: 718-670-1185
Email: mchorost@nyp.org


Backup Contact:

Email: mchorost@nyp.org
Mitchell I Chorost, MD
Phone: 718-670-1185


Location Contact:

Flushing, New York 11355
United States

Mitchell I Chorost, MD
Phone: 718-670-1185
Email: mchorost@nyp.org

Site Status: Recruiting


Data Source: ClinicalTrials.gov

Date Processed: December 08, 2022

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