Louisville, Kentucky 40202

  • Asthma

Purpose:

Project Aim: To determine if intramuscular epinephrine is an effective adjunct to inhaled bronchodilators (β2 agonists) for children with severe asthma exacerbation. Hypothesis: IM epinephrine is an efficacious adjunct to inhaled bronchodilators (β2 agonists) for children with severe asthma exacerbation. Intervention: Subjects will be randomly assigned (50% chance) to receive a weight based dose of IM epinephrine 1:1000 or no adjunctive medication. The dose will be 0.2 mg for subjects 20-30 kg and 0.3 mg for subjects greater than 30 kg. This will be injected intramuscularly by an ED nurse into the anterior thigh muscles of the subject using a 1 ml syringe and a 23 gauge one inch needle. In addition to the study intervention, the standardized treatment pathway based on the current asthma guidelines in use at the investigator's center will be utilized. This pathway includes nebulized albuterol, ipratropium bromide, and systemic corticosteroids. The duration and dosages of these other interventions will be administered at the discretion of the treating provider.


Criteria:

Inclusion Criteria: 1. Age greater than 6 years and less than 18 years 2. Pre-existing diagnosis of asthma 3. Presenting to the ED with an asthma exacerbation Exclusion Criteria: 1. History of chronic lung or upper airway disease other than asthma 2. History significant, uncorrected congenital heart disease or cardiac arrhythmia 3. History of thyroid disease 4. Impending respiratory failure 5. Allergy to epinephrine 6. Pregnancy 7. PEFR>60% of predicted and clinical asthma score less than 8


NCT ID:

NCT01705964


Primary Contact:

Principal Investigator
Kerry Caperell, MD
University of Louisville


Backup Contact:

N/A


Location Contact:

Louisville, Kentucky 40202
United States



There is no listed contact information for this specific location.

Site Status: N/A


Data Source: ClinicalTrials.gov

Date Processed: June 19, 2021

Modifications to this listing: Only selected fields are shown, please use the link below to view all information about this clinical trial.


Click to view Full Listing

This study is not currently recruiting Study Participants on ClinicalConnection.com. The form below is not enabled.