Boston, Massachusetts 02115

  • Sleep Apnea

Purpose:

In obstructive sleep apnea (OSA), the upper airway recurrently closes during sleep. The mechanisms that lead to airway closure are not completely understood. Some studies have shown that there is progressive narrowing of the pharyngeal airway across breaths during expiration (Progressive Expiratory Narrowing, PEN) preceding an obstructive apnea. The investigators will assess the viscoelastic properties of the pharyngeal airway and its role in PEN.


Study summary:

In obstructive sleep apnea, the upper airway recurrently closes during sleep. The mechanisms that lead to airway closure are not completely understood. Some studies have shown that there is progressive narrowing of the pharyngeal airway across breaths during expiration (Progressive Expiratory Narrowing, PEN) preceding an obstructive apnea. The investigators will test how the viscoelastic properties of the airway influence PEN. To this end, the investigators will visualize the pharynx of sleep apnea patients using a thin endoscope and will induce central apneas during sleep. Pharyngeal cross-sectional area will be recorded during incremental changes in pharyngeal pressure during central apneas.


Criteria:

Inclusion Criteria: - Normal subjects or patients with OSA Exclusion Criteria: - Any unstable cardiac condition (other than well controlled hypertension) or pulmonary problems. - Any medication known to influence breathing, sleep/arousal or muscle physiology - Concurrent sleep disorders (insomnia, narcolepsy, central sleep apnea or parasomnia) - Claustrophobia - Inability to sleep supine - Allergy to lidocaine or oxymetazoline hydrochloride - For women: Pregnancy


NCT ID:

NCT01733784


Primary Contact:

Principal Investigator
David A Wellman, MD
Brigham and Women's Hospital


Backup Contact:

N/A


Location Contact:

Boston, Massachusetts 02115
United States



There is no listed contact information for this specific location.

Site Status: N/A


Data Source: ClinicalTrials.gov

Date Processed: June 20, 2021

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