St. Louis, Missouri 63110

  • Postpartum Depression


Perinatal depression is a major public health problem, affecting 15% of women during pregnancy through the postpartum period, with adverse consequences for the mother, the fetus, the infant, and the family. Despite increasing evidence of the importance of this critical risk interval, little research has investigated the effects of depression treatment during pregnancy on infant outcomes. The purpose of this study is to test the feasibility, acceptability, and effectiveness of a new intervention, Interpersonal psychotherapy for the mother-infant dyad (IPT-Dyad). This intervention begins during pregnancy and continues with the mother and infant until one year postpartum. The investigators hypothesize that IPT-Dyad will be better than treatment as usual in reducing depressive symptoms, improving psychosocial functioning,increasing parenting self-efficacy, improving infant emotional development, and enhancing mother-infant relationship quality.


Inclusion Criteria: - Pregnant women - 18 years and older - between 12 and 30 weeks gestation - Score greater than or equal to 13 on Edinburgh Depression Scale - Structured Clinical Interview (SCID-IV) diagnosis of Major Depressive Disorder, dysthymia, or Depressive Disorder, Not otherwise Specified - English Speaking Exclusion Criteria: - Substance abuse or dependence in past 3 months - Active suicidal or homicidal ideation - Bipolar disorder, psychotic disorder - unstable medical condition or other medical/obstetrical complication - Evidence of severe intimate partner violence - Ongoing psychosocial or pharmacotherapy for depression



Primary Contact:

Principal Investigator
Shannon Lenze, Ph.D.
Washington Univeristy

Backup Contact:


Location Contact:

St. Louis, Missouri 63110
United States

There is no listed contact information for this specific location.

Site Status: N/A

Data Source:

Date Processed: June 22, 2021

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