Orlando, Florida 32804

  • Overweight

Purpose:

The purpose of this study is to collect data to help understand why some women develop Polycystic Ovary Syndrome (PCOS) associated with decreased lower-body fat.


Study summary:

Epigenetics may represent a new regulator mechanism explaining gluteal vs. abdominal fat differences.


Criteria:

Inclusion Criteria: - Female - Age > 20 and < 40 - Weight stable (change of less than 3 kg in the last 8 weeks) - BMI < 40 kg/m2 or > 27 kg/m2 Supplemental inclusion criteria for PCOS women: - NIH criteria - confirmed by subjects' medical records. Exclusion Criteria: - Male - Women who are pregnant or lactating (breast feeding) - Post-menopausal women - Women with hysterectomy - Diagnosed with diabetes, or have a fasting blood sugar > 126 mg/dL. - Untreated or symptomatic thyroid disease. - Impaired kidney or liver function, as evidenced by your blood work - Hypertension/ high blood pressure or are taking blood pressure medications - Use of oral contraceptives or hormone replacement therapy. - History of drug or alcohol abuse (> 3 drinks per day) in the last 5 years, or psychiatric disease prohibiting adherence to study protocol. - History of cancer within the last 5 years. - History of organ transplant. - History of HIV, active Hepatitis B or C, or Tuberculosis. - History of heart attack/ myocardial infarction. - Presence of clinically significant abnormalities on EKG. - Current smokers (smoking within the past 3 months) - Use of any medications known to influence glucose, fat and/or energy metabolism within the last 3 months (e.g., growth hormone therapy, glucocorticoids [steroids], etc.). Metformin for women with PCOS is allowed.


NCT ID:

NCT01745471


Primary Contact:

Principal Investigator
Adeline Divoux, PhD
Translational Research Institute for Metabolism and Diabetes


Backup Contact:

N/A


Location Contact:

Orlando, Florida 32804
United States



There is no listed contact information for this specific location.

Site Status: N/A


Data Source: ClinicalTrials.gov

Date Processed: June 24, 2021

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