Columbia, Missouri 65211

  • Insulin Resistance

Purpose:

The effects of physical inactivity on variations in blood glucose and vascular health are not fully understood. The purpose of this study is to determine if an acute transition from physical activity to inactivity alters blood glucose homeostasis and measures of vascular health. Specifically, the investigators wish to examine in healthy, lean physically active individuals (obtaining greater than 10,000 steps/day) if decreasing physical activity (obtaining less than 5,000 steps/day) will alter blood flow following a meal, glycemic control, and a marker of vascular health. Since the investigators know that high blood glucose or large changes in blood glucose following a meal is associated with decreased vascular health, the investigators also wish to determine if the changes in vascular health occur before or after changes in blood glucose following a meal. Furthermore, the investigators wish to examine if a one day return to physical activity (obtaining >10,000 steps/day) can restore the detrimental effects on glycemic control, vascular health, and blood flow following a meal. The investigators anticipate that physical inactivity will decrease glycemic control, vascular health, and blood flow following a meal. Further, the investigators anticipate that with physical inactivity, the investigators will see impairments in glycemic control before the investigators see impairments in vascular health. Finally, the investigators expect that a one day return to physical activity will restore glycemic control, vascular health, and blood flow following a meal back to pre-inactivity levels.


Criteria:

Inclusion Criteria: - BMI: less than 30 kg/m2 - Physically active: exercise greater than 60mins per week Exclusion Criteria: - smoking - type 2 diabetes - Underlying conditions that limit ability to exercise safely - Recent weight gain or loss(> 5% of body weight in 3 months) - Recent (< 3 mo) changes in medication use or dose - Pregnancy


NCT ID:

NCT01879059


Primary Contact:

Principal Investigator
John P Thyfault, PhD
University of Missouri-Columbia

John P Thyfault, PhD
Phone: 573-882-6892
Email: umchesexphysstudy@missouri.edu


Backup Contact:

N/A


Location Contact:

Columbia, Missouri 65211
United States

John P Thyfault, PhD
Phone: 573-882-6892
Email: umchesexphysstudy@missouri.edu

Site Status: Recruiting


Data Source: ClinicalTrials.gov

Date Processed: August 03, 2021

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