Kansas City, Kansas 66160

  • End Stage Renal Disease


The purpose of this study is to understand cognitive impairment in end stage renal disease before and after a kidney transplant.

Study summary:

Cognitive impairment is very common in patients with End Stage Renal Disease (ESRD). It exact mechanisms are not clear, but patients with ESRD have more cerebral white matter changes. Several studies have shown that cognitive function improves post-transplant, indicating that there may be some reversibility in the process. This study will examine the correlation between cognitive impairment and structural brain changes before and after renal transplantation. We will also study the correlation of cognitive function with serum inflammatory markers before and after transplant. These results will be compared to aged matched healthy controls without kidney disease.


Inclusion Criteria: - Pre-transplant ESRD patients between the ages of 30 and 70 years who are listed for renal transplantation - Able to sign pre-transplant consent on their own will - Have english as their native language Exclusion Criteria: - Current use of antipsychotics or anti-epileptics - Inability to read or write which will limit their ability to perform the cognitive tests - Claustrophobia or inability to get MRI for other reasons - Unable to sign consent



Primary Contact:

Principal Investigator
Aditi Gupta, MD
University of Kansas Medical Center

Andrew Jurgensen, BS
Phone: 913-574-0895
Email: ajurgensen@kumc.edu

Backup Contact:


Location Contact:

Kansas City, Kansas 66160
United States

There is no listed contact information for this specific location.

Site Status: Recruiting

Data Source: ClinicalTrials.gov

Date Processed: July 27, 2021

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