Denver, Colorado


The purpose of this study is to identify potential markers for curve progression in adolescent idiopathic scoliosis (AIS). Despite its prevalence and impact on child health, the etiology of AIS and molecular mechanisms underlying its development and progression remain poorly understood. Clinical criteria and features cannot adequately predict which children, diagnosed with mild disease, will undergo subsequent curve progression requiring intervention. The investigators hypothesize that alterations in specific genetic markers will be correlated with the progression of AIS curves over time. Thus, these markers could be used in the future to develop a reliable, inexpensive and relatively non-invasive cell based diagnostic test to (1) predict spinal curve progression in AIS, (2) select patients likely to benefit from early surgical intervention, and (3) potentially screen for asymptomatic children at risk of developing idiopathic scoliosis.


Inclusion Criteria: - Females aged 10-13 years - Diagnosed with mild-moderate spine deformity (Cobb angle 15-30 degrees) Exclusion Criteria: - Patients with scoliosis other than idiopathic - Trauma - Inflammatory disease - Malignancies - Diabetes - History of previous spine surgery



Primary Contact:

Principal Investigator
Evalina L Burger, MD
University of Colorado - Anschutz Medical Campus

Claire Cofer
Phone: 303-724-1588

Backup Contact:


Location Contact:

Denver, Colorado
United States

There is no listed contact information for this specific location.

Site Status: Recruiting

Data Source:

Date Processed: October 18, 2018

Modifications to this listing: Only selected fields are shown, please use the link below to view all information about this clinical trial.

Click to view Full Listing

This study is not currently recruiting Study Participants on The form below is not enabled.