Kansas City, Kansas 66160

  • Multisystem Proteinopathy

Purpose:

The goals of this study are: (1) to better understand the relationship between the phenotype and genotype of amyotrophic lateral sclerosis (ALS) and related diseases, including primary lateral sclerosis (PLS), hereditary spastic paraplegia (HSP), progressive muscular atrophy (PMA), and frontotemporal dementia (FTD); and (2) to develop biomarkers that might be useful in aiding therapy development for this group of disorders.


Study summary:

This study will recruit patients with ALS, ALS-FTD, PLS, HSP, and PMA, with a focus on incident cases. Patients with both familial and sporadic forms of these diseases will be enrolled and followed longitudinally using a standardized set of evaluations. Biological samples (blood, urine, CSF) will be collected from all study participants, and will be used for biomarker discovery and validation. Family members of affected individuals may also be enrolled and asked to contribute DNA and biological samples to aid genetic and biomarker discovery.


Criteria:

Inclusion Criteria: - Member of at least one of the following categories: 1. Individuals with a clinical diagnosis of ALS or a related disorder, including FTD, HSP, PLS, PMA and MSP (sporadic or familial). 2. Family member of an enrolled affected individual. - Able and willing to comply with relevant procedures. Exclusion Criteria: - Affected with end or late stage disease. - A condition or situation which, in the PI's opinion, could confound the study finding or may interfere significantly with the individual's participation and compliance with the study protocol. This includes (but is not limited to) neurological, psychological and/or medical conditions.


NCT ID:

NCT02327845


Primary Contact:

Principal Investigator
Michael Benatar, DPhil
University of Miami

Michael Benatar, DPhil
Phone: 305-243-4015


Backup Contact:

Email: projectcreate@med.miami.edu
Sumaira Hussain
Phone: 1-844-837-1031


Location Contact:

Kansas City, Kansas 66160
United States

Collin Gerringer
Phone: 913-748-5701
Email: cgerringer@kumc.edu

Site Status: Recruiting


Data Source: ClinicalTrials.gov

Date Processed: September 25, 2021

Modifications to this listing: Only selected fields are shown, please use the link below to view all information about this clinical trial.


Click to view Full Listing

If you would like to be contacted by the clinical trial representative please fill out the form below.