Boston, Massachusetts 02215


Purpose:

The overall goal of this study is to open up the promising treatment of repetitive transcranial magnetic stimulation (rTMS), which has been shown to be effective against seizures in patients with surface neocortical foci, to a much larger population of patients with mesial temporal lobe epilepsy (MTLE) and other forms of epilepsy with deep foci, who are not currently considered good rTMS candidates. The investigators hypothesize that rTMS can modulate the hyperexcitable state in patients with deep seizure foci by targeting its usage to accessible cortical partner regions. In this study the investigators aim 1) to map the functional connectivity of the epileptogenic mesial temporal lobe in patients with medically refractory mesial temporal lobe epilepsy; and 2) to perform a randomized controlled assessment of repetitive transcranial magnetic stimulation protocols applied to specific neocortical targets in mesial temporal lobe epilepsy. The methods used in this study will include magnetic resonance imaging (MRI) of the brain, electroencephalography (EEG), and transcranial magnetic stimulation (TMS).


Criteria:

Inclusion Criteria: - Diagnosis of mesial temporal lobe epilepsy based on the combination of clinical semiology, neuroimaging findings, and electroencephalogram results. - At least 1 seizure with loss of awareness per 4-week period, on average, despite the use of antiepileptic drugs Exclusion Criteria: - Prior brain surgery or exposure to transcranial magnetic stimulation - Rapidly progressive brain lesions - Inability to tolerate MRI or TMS - Specific MRI or TMS contraindication as set forth in standard protocols of our institution


NCT ID:

NCT02339376


Primary Contact:

Principal Investigator
Bernard S Chang, MD, MMSc
Beth Israel Deaconess Medical Center

Bernard S Chang, MD, MMSc
Phone: 617-667-2889
Email: bchang@bidmc.harvard.edu


Backup Contact:

N/A


Location Contact:

Boston, Massachusetts 02215
United States

Bernard S Chang, MD, MMSc
Phone: 617-667-2889
Email: bchang@bidmc.harvard.edu

Site Status: Recruiting


Data Source: ClinicalTrials.gov

Date Processed: June 25, 2018

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