Expired Study
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Durham, North Carolina 27710


The purpose of this study is to demonstrate the clinical feasibility of low amplitude electroconvulsive therapy (ECT) to reduce, and possibly eliminate the side effects of ECT by lowering the strength of the ECT stimulus from the conventional 800 mA to 500 mA. Low amplitude ECT could potentially reduce the risks associated with ECT while preserving its unparalleled efficacy. This novel development would remove key obstacles to allow for the wider adoption of ECT as a safe and effective therapy.


Inclusion Criteria: 1. Male and female subjects, age 18-70 2. DSM-IV-TR diagnosis of major depressive episode in unipolar or bipolar disorder, confirmed by the MINI-PLUS 3. MMSE total score > 26 4. Referred for ECT 5. Competent to provide informed consent 6. Able to read or comprehend English Exclusion Criteria: 1. Lifetime history of schizophrenia, schizoaffective disorder, mental retardation 2. Current neurostimulation treatment (e.g., ECT, magnetic seizure therapy, transcranial magnetic stimulation, vagus nerve stimulation, deep brain stimulation) 3. Current alcohol abuse or dependence within past 6 months 4. Current substance abuse or dependence within past 6 months 5. History of central nervous system (CNS) disease 6. Current diagnosis of dementia or delirium 7. MoCA total score < 26 8. Current visual, auditory, or motor impairment that compromises ability to complete evaluations 9. Patients with intracranial implants 10. MRI contraindications: pregnancy, implanted metal, and claustrophobia



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Durham, North Carolina 27710
United States

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Site Status: N/A

Data Source: ClinicalTrials.gov

Date Processed: January 21, 2020

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