Expired Study
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Rochester, Minnesota 55905


The purpose of this study is to find out if giving a medicine called furosemide, which is a diuretic or water pill, after colon surgery will safely shorten the patient's length of hospital stay.

Study summary:

This study will assess if administration of a loop diuretic, specifically furosemide, to achieve euvolemia can safely reduce length of stay following colorectal surgery.


Inclusion Criteria - All elective colorectal surgeries (CRS) utilizing the enhanced recovery pathway (ERP) - The surgery involves resection Exclusion Criteria Exclusion Criteria for Randomization: - Surgeries involving intraoperative radiation - Ileostomy closures, when performed as the only surgical intervention - Surgeries involving multiple disciplines (e.g., colorectal plus general surgery, colorectal plus gynecology surgery) except for colorectal surgeries plus ureteral stent placements. - Chronic loop diuretic therapy (i.e., bumetanide, torsemide, furosemide, ethacrynic acid) including as needed administration of such therapy - Patients receiving dialysis - Creatinine clearance, calculated by the Cockcroft-Gault equation, less than 30 mL/min. - Inpatient prior to surgery - Allergy to furosemide - Allergy to sulfa drugs if the allergy involves anaphylactic reaction - Lack of serum creatinine concentration within 3 months preceding the surgery AND diagnosis of chronic kidney disease Exclusion Criteria for Intervention (applies to both the intervention and control arm): - Patient's weight on postoperative day (POD) #1 and POD #2 is less than preoperative weight. - Blood pressure criteria: systolic blood pressure criteria less than 90 mmHg or greater than 30 mmHg below baseline on POD #1 and/or POD #2 immediately prior to administration of study drug. - Complications within 48 hours of surgery - Abscess (infected fluid collection, treated with CT drainage) - Leak (defined by CT drainage or reoperation) - Wound infection (treated with either antibiotics and/or open packing) - Bowel obstruction (treated with reoperation) - Reoperation - Hemorrhage - Weight change since admission on POD #1: > 5 kg - Acute kidney injury on POD #1 and POD#2 defined as serum creatinine (SCr) increase ≥ 0.3 mg/dL or increase to ≥ 150% to 200% (1.5- to 2-fold) from baseline



Primary Contact:

Principal Investigator
Ilya Danelich, PharmD, RPh
Mayo Clinic

Backup Contact:


Location Contact:

Rochester, Minnesota 55905
United States

There is no listed contact information for this specific location.

Site Status: N/A

Data Source: ClinicalTrials.gov

Date Processed: November 18, 2019

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