Hershey, Pennsylvania 17033


This research is being done to find out how effective Prazosin is in the treatment of bulimic patients experiencing distressing nightmares using subjective and objective measures.

Study summary:

To the investigators knowledge, there is no treatment trial for prazosin use in patients with bulimia nervosa struggling with nightmares, looking at either objective or subjective measures. The investigators plan to probe the effectiveness of prazosin in bulimic patients experiencing nightmares due to PTSD using both subjective and objective measures in order to improve future clinical care. The effects of prazosin on decreasing nightmares and bulimic symptoms on subjective scales and effects on sleep architecture using objective polysomnogram (PSG) measurements will help inform targeted psychopharmacologic and psychotherapeutic strategies to improve clinical care of bulimic patients struggling with distressing dreams secondary to PTSD. This study will be performed in two phases. Phase A will involve eight participants who will be tested using subjective scales (mentioned below). If Phase A data analysis leads to detection of a signal of efficacy 2 more participants will be recruited to participate in phase B of this trial using objective polysomnogram measurements. The results from this project will aid in establishing a fully powered clinical trial for treatment of nightmares in bulimic patients and improve outcomes in this high risk population.


Inclusion Criteria: - Age 18-45 - Clinical diagnosis of Bulimia Nervosa with complaint of nightmares secondary to PTSD Exclusion Criteria: - Restless leg syndrome - Narcolepsy - Sleep Apnea - Neurological disorders - Pregnancy - cardiac abnormalities - significant electrolyte abnormalities - Use of steroids, beta blockers, prazosin - Alcohol/substance abuse



Primary Contact:

Principal Investigator
Fauzia Mahr
Penn State College of Medicine, Milton S. Hershey Medical Center

Fauzia Mahr, MD
Phone: 717 531-8133
Email: fmahr@hmc.psu.edu

Backup Contact:

Email: ccriley@psu.edu
Carrie Criley, BA
Phone: 717 531-4123

Location Contact:

Hershey, Pennsylvania 17033
United States

Fauzia Mahr, MD
Phone: 717-531-8133
Email: fmahr@mnc.psu.edu

Site Status: Recruiting

Data Source: ClinicalTrials.gov

Date Processed: June 25, 2018

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