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Aurora, Colorado 80045


This study plans to learn more about the brain function related to thinking problems in individuals with Parkinson's disease.

Study summary:

Dementia is the leading cause of nursing home placement in Parkinson's disease (PD) yet little is known about the cause(s) of cognitive dysfunction in PD and there are no effective treatments. The investigators preliminary data and other published studies suggest that abnormalities in brain activity involving networks important for normal thinking and memory may contribute to cognitive dysfunction in PD and may represent a target for treatment. This proposal will identify abnormalities in cortical activity related to cognitive dysfunction in PD using magnetoencephalography and will perform a randomized control trial of bifrontal repetitive transcranial magnetic stimulation to determine the therapeutic potential of modulating this brain activity.


Inclusion Criteria: - Diagnosis of probable PD (using United Kingdom Brain Bank criteria) - Diagnosis of mild cognitive impairment - No unstable medical condition Exclusion Criteria: - Features suggestive of other causes of Parkinsonism or other neurological disorders - Prior deep brain stimulation (DBS) or ablation surgery - Evidence for active depression or Hospital Anxiety and Depression Scale (HADS) score greater than or equal to 11 - Motor symptoms expected to interfere with scanning (e.g. sever tremor) - Contraindications to TMS, MEG, or MRI such as pregnancy, pacemaker, unstable cardiac disease, skull lesion, claustrophobia, history of epilepsy, or on medications known to lower seizure threshold - Implanted electronic devices or metal



Primary Contact:

Principal Investigator
Benzi M Kluger, MD, MS
University of Colorado School of Medicine

Backup Contact:


Location Contact:

Aurora, Colorado 80045
United States

There is no listed contact information for this specific location.

Site Status: N/A

Data Source: ClinicalTrials.gov

Date Processed: June 25, 2018

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