Portland, Oregon


The measurement of limb skeletal muscle perfusion and perfusion reserve during exercise is an approach that can assess the total impact of the complex pathophysiologic processes in patients with limb ischemia, particularly in those with diabetes in whom distal arterial disease and abnormal microvascular functional responses are common. This trial is designed to: (a) optimize methods for assessment of limb perfusion at rest and during stress using contrast-enhanced ultrasound (normal subjects) and a microbubble contrast agent that is able to provide non-linear signal without destruction at medium acoustic pressures, and (b) to test whether perfusion imaging provides incremental information on the severity of disease in patients with peripheral artery disease.


Inclusion Criteria: - For Healthy controls: no active major medical problems or vasoactive medications - For PAD: Known diagnosis with PAD an ABI of 0.4-0.6 Exclusion Criteria: - Rutherford class 6 or greater - Allergy to ultrasound contrast agents - Previous limb amputation - Pregnancy - Known congenital or acquired right to left shunt



Primary Contact:


Backup Contact:


Location Contact:

Portland, Oregon
United States

Jonathan Lindner, MD
Phone: 503-494-8750
Email: lindnerj@ohsu.edu

Site Status: Recruiting

Data Source: ClinicalTrials.gov

Date Processed: January 21, 2020

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