Irvine, California 92612

  • Collagen Fibril Alteration


The researchers will assess the effects of treatment with tretinoin cream on human skin by using non-invasive optical imaging technologies.

Study summary:

The researchers will evaluate changes in the dermis and skin properties as the effect of treatment with Tretinoin cream (0.1%) by using the following optical imaging techniques. 1. Multiphoton microscopy using a clinical tomograph (MPTflex, Jenlab, Germany) 2. Multispectral Imaging using a device developed at Beckman Laser Institute, UC Irvine


Inclusion Criteria: - Female 45 years of age or older - Skin type scale I to III Exclusion Criteria: - Large amount of dark, coarse hair on the arms - History of allergies to alpha hydroxy acids (AHAs), retinoids, soaps, fragrances, sunscreens or Latex - Currently using over-the-counter AHA or retinol within one month or prescription retinoid within three months of the start of the study. - History of skin cancer, including squamous or basal cell carcinoma at the treatment site or history of malignant melanoma. - History of diabetes - Currently pregnant or nursing



Primary Contact:

Principal Investigator
Mihaela Balu, PhD
Beckman Laser Institute, UCI

Mihaela Balu, PhD
Phone: 949.824.8797

Backup Contact:

Ata Sharif, MD
Phone: 949 824 9265

Location Contact:

Irvine, California 92612
United States

Mihaela Balu, PhD
Phone: 949-824-8797

Site Status: Recruiting

Data Source:

Date Processed: September 17, 2021

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