Expired Study
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Fullerton, California 92835


Purpose:

The purpose of this study is to determine whether the combination of MM-141 plus nab-paclitaxel and gemcitabine is more effective than nab-paclitaxel and gemcitabine alone based on Progression Free Survival (PFS) in front-line metastatic pancreatic cancer patients with high serum levels of free IGF-1.


Study summary:

This is a randomized, double-blind, placebo-controlled Phase 2 study of MM-141 plus nab-paclitaxel and gemcitabine or placebo plus nab-paclitaxel and gemcitabine in front-line metastatic pancreatic cancer. All patients will be initially screened for free IGF-1 status. Eligible patients with high free IGF-1 will be randomized to receive MM-141 plus nab-paclitaxel and gemcitabine or placebo plus nab-paclitaxel and gemcitabine and patients. Patients with low free IGF-1 or patients who have high free IGF-1 but are not otherwise eligible will be followed in an observational group.


Criteria:

Inclusion Criteria: - Metastatic adenocarcinoma of the pancreas. Patients with islet cell neoplasms are not eligible. - Patient must have received no prior radiotherapy, surgery, chemotherapy, or investigational therapy for the treatment of metastatic disease. - Blood sample sent for free IGF-1 testing - ECOG performance status (PS) of 0 or 1 Exclusion Criteria: - Patients who only present with localized disease - Patients with CNS malignancies (primary or metastatic) - Clinically significant cardiac disease


NCT ID:

NCT02399137


Primary Contact:

Study Director
MM-141 Medical Director, MD
Merrimack Pharmaceuticals


Backup Contact:

N/A


Location Contact:

Fullerton, California 92835
United States



There is no listed contact information for this specific location.

Site Status: N/A


Data Source: ClinicalTrials.gov

Date Processed: January 21, 2020

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