Palo Alto, California 94304

  • Complex Regional Pain Syndrome


The investigators are testing treatment with low-dose naltrexone (LDN) for symptom relief of complex regional pain syndrome (CRPS). Study participants will be randomly assigned to receive either LDN or placebo for a period of several weeks. During this period participants will be asked to come to several visits, which will include sensory testing, physical assessments, and questionnaires.


Inclusion Criteria: - Upper and/or lower extremity CRPS - On stable treatment for 3 months - CRPS for at least 1 year - Meet the Budapest criteria for CRPS at time of the study. Exclusion Criteria: - Any known allergy to naltrexone or naloxone - Use of prescription opioid analgesics or illegal opioid use - Current of planned pregnancy.



Primary Contact:

Principal Investigator
Sean Mackey, MD, PhD
Stanford University

Aaron Yue, MD
Phone: (650) 497-0485

Backup Contact:


Location Contact:

Palo Alto, California 94304
United States

Aaron Yue, MD
Phone: 650-497-0485

Site Status: Recruiting

Data Source:

Date Processed: September 23, 2021

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