Expired Study
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Washington, District of Columbia 20057


The purpose of this study is to determine whether molecular profile-directed therapy (otherwise known as personalized treatment) can improve the effectiveness of standard chemotherapy combinations for patients with esophagogastric adenocarcinoma. A series of tests will be performed on a sample of tumor; based on the results of these tests, a patient will be assigned to a chemotherapy treatment.


Inclusion Criteria: - Advanced, measurable metastatic esophagogastric adenocarcinoma by RECIST criteria - Patients who have had surgery or radiotherapy with or without neoadjuvant or adjuvant chemotherapy (the wash-out period will be at least 1 month) - Patients who are not eligible for resection and are chemotherapy naïve - Patients with HER2(-) status - Patients who have tumor deposit(s) that are easily accessible by ultrasound or CT guidance - Patients must have adequate organ function - Patients must provide written informed consent Exclusion Criteria: - Active concurrent malignancy, other than superficial, non-squamous cell carcinoma of the skin or uterine cervix, within the past three years - ECOG performance status worse than 2 - Prior oral or intravenous chemotherapy for metastatic disease - Patients with comorbidities that prevent them from being able to receive the chemotherapy regimen - cardiac ejection fraction 45% or greater



Primary Contact:

Principal Investigator
John Marshall, MD
Georgetown University

Backup Contact:


Location Contact:

Washington, District of Columbia 20057
United States

There is no listed contact information for this specific location.

Site Status: N/A

Data Source: ClinicalTrials.gov

Date Processed: January 21, 2020

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