Expired Study
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Knoxville, Tennessee 37922


Purpose:

The purpose of this study is to assess the efficacy of dexmedetomidine versus propofol for prolonged sedation in trauma and surgical patients.


Study summary:

Design: Open-label, single-center prospective study. Setting: Trauma/Surgical Intensive Care Unit (TSICU) at a Level I academic trauma center. Patients: Patients 18 years of age or older requiring mechanical ventilation and admitted to the TSICU Interventions: Patients were randomly assigned based on unit bed location to receive dexmedetomidine or propofol for sedation.


Criteria:

Inclusion Criteria: - Patients were included in the study if they were 18 years of age or older, - mechanically ventilated, - placed on the institutional sedation protocol, - expected to require sedation lasting 24 hours after randomization, and - admitted to the TSICU and followed by the Trauma/Surgical Service. Exclusion Criteria: Patients were excluded for any of the following: - 72 hours or greater since sedation protocol initiation, - treatment per the institutional traumatic brain injury (TBI) protocol, - concomitant continuous infusion of a neuromuscular blocking agent, - heart rate less than 50 beats per minute, - mean arterial pressure less than 55 mmHg despite fluid resuscitation and vasopressors, and - use of other alpha-2 agonists within 24 hours of randomization.


NCT ID:

NCT02548923


Primary Contact:

N/A


Backup Contact:

N/A


Location Contact:

Knoxville, Tennessee 37922
United States



There is no listed contact information for this specific location.

Site Status: N/A


Data Source: ClinicalTrials.gov

Date Processed: November 18, 2019

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