Miami, Florida 33136


Purpose:

The investigators would like to determine if remote ischemic leg preconditioning in healthy volunteers improves cerebral vasomotor reactivity as measured by breath holding and transcranial doppler vasomotor reactivity.


Study summary:

This study is to determine if remote ischemic leg preconditioning improves short and long term cerebral vasomotor reactivity in healthy volunteers as measured by breath holding and transcranial doppler vasomotor reactivity. Previous studies on brachial vasomotor reactivity have shown a beneficial effect of remote ischemic preconditioning. It remains uncertain if a similar beneficial effect can be reproduced with cerebral vasomotor testing. Many biological mechanisms and effector pathways triggered by preconditioning have demonstrated endothelial protection and beneficial vascular effects.


Criteria:

Inclusion Criteria: - Healthy volunteers Exclusion Criteria: - Presence of chronic medical conditions such as diabetes, hypertension, cardiac disease etc. - Any prescribed medication - Pregnancy [by history and last menstrual period] - Any leg injury that would, in the opinion of the investigator, affect preconditioning


NCT ID:

NCT02553655


Primary Contact:

Principal Investigator
Sebastian Koch, MD
University of Miami

Sebastian Koch, MD
Phone: 305-243-6732
Email: skoch@med.miami.edu


Backup Contact:

Email: mayodele@med.miami.edu
Maranatha Ayodele, MD
Phone: 305-243-6732


Location Contact:

Miami, Florida 33136
United States

Sebastian Koch, MD
Phone: 305-243-6732
Email: skoch@miami.edu

Site Status: Recruiting


Data Source: ClinicalTrials.gov

Date Processed: January 21, 2020

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