New York, New York 10032


Purpose:

The purpose of this study is to test the effects of the drug gabapentin on brain function thought to be important in the development of schizophrenia. Researchers think that treating a brain region with gabapentin (the hippocampus) may reduce the risk for developing schizophrenia.


Criteria:

Inclusion Criteria: 1. COPE patient between age of 18-30 2. Capacity to give informed consent 3. Currently using a reliable method of birth control (female) (condom plus spermicide, diaphragm plus spermicide, IUD, birth control pills, norplant, vasctomy in partner) Exclusion Criteria: 1. Metal implants in body or a history of metal working, or more than one past MRI scan with gadolinium 2. Lifetime diagnosis of asthmatic symptoms within the past 3 years or known sensitivity to contrast agents 3. Lifetime diagnosis of renal failure/disease 4. Acute neurological, neuroendocrine,or medical disorder including renal insufficiency 5. Lifetime diagnosis of hypertension or diabetes 6. Intelligence Quotient (IQ) < 70 7. Acute risk for suicide and/or violence 8. Pregnant, lactating 9. Current abuse of substances (alcohol, cocaine, stimulants, cannabis, opiates, sedative hypnotics) 10. Current use or anticipated need for antipsychotics or mood stabilizers (all antipsychotics, also Depakote, lithium, lamotrigine, pregabalin or any med with a mechanism of action like gabapentin) 11. The Clinical Global Impressions Scale (CGI)-improvement score during study equal to or greater than 6


NCT ID:

NCT02557945


Primary Contact:

Principal Investigator
Ragy Girgis, M.D.
NYSPI/Columbia

Gary Brucato, PhD
Phone: 646-774-5232


Backup Contact:

N/A


Location Contact:

New York, New York 10032
United States

Gary Brucato, PhD
Phone: 646-774-5232
Email: gb2428@columbia.edu

Site Status: Recruiting


Data Source: ClinicalTrials.gov

Date Processed: January 21, 2020

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