Philadelphia, Pennsylvania 19104


Currently, standard-of-care tractography is based on information obtained from diffusion tensor imaging (DTI). DTI is a diffusion magnetic resonance imaging (dMRI) technique that is routinely obtained on neurosurgical patients to assist in pre-operative planning. The primary objective of the proposed study is to determine the ability of msHARDI-based tractography to discern fibers in edematous brain regions.


Inclusion Criteria: - brain lesions, including but not limited to tumors, epileptic foci, and vascular abnormalities, in or around eloquent brain regions (i.e., motor, language); - clinical need for pre-operative 'advanced imaging' (which includes conventional DTI); - age between 18-80 years of age; - male or female gender. Eloquent regions include: Temporal and frontal lobes (speech/language); bilateral occipital lobes (vision); bilateral parietal lobes (sensation); and bilateral motor cortex (movement). Exclusion Criteria: - a contraindication for obtaining an MRI scan (e.g. implanted devices, retrained foreign body) - pregnancy - absence of the capacity to make medical decisions or provide informed consent.



Primary Contact:

Principal Investigator
Steven Brem, MD
Abramson Cancer Center of the University of Pennsylvania

Steven Brem, MD
Phone: 855-216-0098

Backup Contact:


Location Contact:

Philadelphia, Pennsylvania 19104
United States

Steven Brem, MD
Phone: 215-614-0458

Site Status: Recruiting

Data Source:

Date Processed: November 18, 2019

Modifications to this listing: Only selected fields are shown, please use the link below to view all information about this clinical trial.

Click to view Full Listing

If you would like to be contacted by the clinical trial representative please fill out the form below.