Expired Study
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Los Angeles, California 90032


Socioemotional processing dysfunctions (i.e., disruptions in affective, cognitive, and neural processes that encode, interpret, and respond to socially and emotionally relevant stimuli) have been implicated in tobacco smoking and relapse, however this potential target for medication development has not been systematically examined. Evidence from animal and human laboratories indicate that administration of intranasal oxytocin enhances socioemotional processing and may be efficacious for the treatment of drug addiction, including nicotine dependence. In order to evaluate the potential efficacy of intranasal oxytocin for smoking cessation, this laboratory-based proposal will examine whether intranasal oxytocin attenuates smoking lapse, nicotine withdrawal, and socioemotional processing disruptions in regular smokers following overnight abstinence.


Inclusion Criteria: - Ages 18-40 - Smoke >= 10 cig/day for the past year - English fluency Exclusion Criteria: - Current DSM-5 substance use disorder, excluding nicotine dependence (to minimize alcohol or drug withdrawal symptoms during the study sessions) - Any medical condition that would increase risk for study participation (such as sinus infection or other condition blocking access to the olfactory epithelium) - Women who are pregnant or nursing - Current use of psychiatric medication - Breath Carbon Monoxide (CO) levels < 10ppm measured during study intake (to exclude individuals who overreport smoking in order to participate in the study) - Planning to quit or reduce smoking in the next 30 days - Current regular use of other nicotine products



Primary Contact:

Principal Investigator
Matthew Kirkpatrick, PhD
University of Southern California

Backup Contact:


Location Contact:

Los Angeles, California 90032
United States

There is no listed contact information for this specific location.

Site Status: N/A

Data Source: ClinicalTrials.gov

Date Processed: January 21, 2020

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