Expired Study
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Boulder, Colorado 80309


Purpose:

The purpose of this study is to assess the efficacy of supplementation with the mitochondria-targeted antioxidant, mitoquinone (MitoQ), for improving physiological function (vascular, motor, and cognitive) in middle-aged and older adults.


Study summary:

Overall, the proposed research project has the long-term potential to influence clinical practice by establishing novel therapies for treating multiple domains of age-associated physiological dysfunction and thereby reducing the risk of clinical disease and disability.


Criteria:

Inclusion Criteria: - Women will be confirmed as postmenopausal (either natural or surgical) based on cessation of menses for >1 year. - Ability to provide informed consent - Baseline brachial flow-mediated dilation (FMD) < 6%Δ (rationale: non-invasive screening to ensure exclusion of subjects with exceptionally high baseline endothelial function. - Ability to perform motor and cognitive tests (e.g., can rise from a chair, walk for 2 min, climb 10 stairs) - Willing to accept random assignment to condition Exclusion Criteria: - Current smoking - Having past or present alcohol dependence or abuse, as defined by the American Psychiatry Association, Diagnostic and Statistical Manual of Mental Disorders - Body mass index (BMI) >40 kg/m2 (FMD measurements can be inaccurate in severely obese patients) - Chronic clinical diseases (e.g., coronary artery/peripheral artery/cerebrovascular diseases, diabetes, chronic kidney disease requiring dialysis, neurological disorders or diseases that may affect motor/cognitive functions [multiple sclerosis, Parkinson's disease, polio, Alzheimer's disease, dementia or other brain diseases of aging]), except hypertension and hyperlipidemia - Regular vigorous aerobic/endurance exercise (>3 vigorous bouts/week). - Not weight stable in the prior 3 months (>2 kg weight change) or unwilling to remain weight stable throughout study (rationale: recent weight change or weight loss can influence vascular function. - Current treatment or recent cessation (< 3 mo) of hormone replacement therapy - Moderate or severe peripheral artery disease (ankle-brachial index <0.7). - A graded exercise test will be performed by all subjects, if there is physician concern or an adverse event, the subject will not participate in a maximal oxygen consumption (VO2max) test (this will be determined in accordance with stated contraindications for exercise testing provided by the American Heart Association). - Thyroid disease that is not controlled by medications or <3 month's use of a particular medication and/or dosage (uncontrolled thyroid diseases are associated with alterations in vascular function).


NCT ID:

NCT02597023


Primary Contact:

Study Director
Matthew J Rossman, PhD
University of Colorado, Boulder


Backup Contact:

N/A


Location Contact:

Boulder, Colorado 80309
United States



There is no listed contact information for this specific location.

Site Status: N/A


Data Source: ClinicalTrials.gov

Date Processed: January 21, 2020

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