Rochester, Minnesota 55905


Transcatheter aortic valve replacement (TAVR) is a treatment alternative among high-risk elderly with aortic stenosis, however, mortality remains high. Fifty percent of patients undergoing TAVR exhibit frailty, a syndrome associated with poor survival. It is unknown whether interventions to improve frailty before TAVR (prehabilitation) will improve outcomes after TAVR. This study plans to evaluate whether simple cardiac exercise interventions to improve physical performance before TAVR improves outcomes after TAVR.


Inclusion criteria: - Eligibility for TAVR - SPPB<9 - Able to exercise - Able to come for follow-up visits - Able to give informed consent Exclusion criteria: - New York Heart Association (NYHA) Class III/IV congestive heart failure (CHF) - Presyncope or syncope as presentation - Acute coronary syndrome - Unable to exercise - Dementia - Sustained ventricular arrhythmia - Stroke with neurological deficit - Advanced Parkinson's - Participated in an exercise program



Primary Contact:

Principal Investigator
Mandeep Singh, MD
Mayo Clinic

Backup Contact:


Location Contact:

Rochester, Minnesota 55905
United States

Mandeep Singh, MD, MPH
Phone: 507-255-5891

Site Status: Recruiting

Data Source:

Date Processed: January 21, 2020

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