Expired Study
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Los Angeles, California 90048


Previous research has identified spontaneous cerebral spinal fluid leakage as a cause for spontaneous intracranial hypotension, leading to positional headache patterns. Typical magnetic resonance imaging findings include subdural fluid collections, enhancement of pachymenginges, engorgement of venous structures, pituitary hyperemia, and sagging of the brain (SEEPS). Because pituitary hyperemia has been documented in cases of spontaneous cerebral spinal fluid leakage and is known to mimic a pituitary tumor or hyperplasia, the investigators would like to like to assess the clinical manifestations and neuroimaging abnormalities of SIH patients with regard to the pituitary gland. Specifically, the investigators are looking to analyze the compression of the pituitary stalk and conduct a systemic evaluation of pituitary function in SIH patients.


Inclusion Criteria: - Male or female patients - Age 18 years and older - Diagnosis of SIH: - LP - Brain MRI (SEEPS) Exclusion Criteria: - Pregnant and post-partum females - Nursing mothers - Patients with potential hyperprolactinemia due to: - Hypothyroidism, - Chronic renal disorder - Liver disease (including cirrhosis) - Primary or secondary amenorrhea - Polycystic Ovary Syndrome - Seizure disorder - Illicit drug use



Primary Contact:

Principal Investigator
Vivien Bonert, MD
Cedars-Sinai Medical Center

Backup Contact:


Location Contact:

Los Angeles, California 90048
United States

There is no listed contact information for this specific location.

Site Status: N/A

Data Source: ClinicalTrials.gov

Date Processed: January 21, 2020

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