Boston, Massachusetts 02215


Purpose:

This research trial studies whole exome sequencing in finding causative variants in germline deoxyribonucleic acid (DNA) samples from patients with peripheral neuropathy receiving chemotherapy for breast cancer. Studying samples of germline DNA in the laboratory from patients with peripheral neuropathy receiving paclitaxel for breast cancer may help doctors learn more about changes that occur in DNA and identify biomarkers related to peripheral neuropathy.


Study summary:

PRIMARY OBJECTIVES: I. To identify, using next generation sequencing, rare variants of large effect size that impact the risk of peripheral neuropathy in patients of African and European descent in the clinical trial ECOG-5103 (E5103). OUTLINE: Previously collected germline DNA samples are analyzed via whole exome sequencing.


Criteria:

Inclusion Criteria: - European American patients with DNA available and designated case or control - African American patients with DNA available and designated case or control status - Patients who developed grade 2-4 for African American (AA) and grade 3-4 for European American (EA) peripheral neuropathy during their treatment with paclitaxel and who did not develop peripheral neuropathy following a full course of treatment with paclitaxel


NCT ID:

NCT02610439


Primary Contact:

Principal Investigator
Bryan P Schneider
Eastern Cooperative Oncology Group


Backup Contact:

N/A


Location Contact:

Boston, Massachusetts 02215
United States

Bryan P. Schneider
Phone: 317-274-6473
Email: bpschnei@iupui.edu

Site Status: Recruiting


Data Source: ClinicalTrials.gov

Date Processed: January 21, 2020

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